On the one side, Real Madrid are top of the league with a three point cushion and a game in hand.
They're through to the Champions League semis, and everything looks gravy right now for the Merengues.
Will he go with a back three or a back four against Madrid?
One of Enrique's biggest issues is how to handle the overload of Marcelo and Cristiano Ronaldo on the right side of his defense.
Barcelona have struggled in that area all season, and the one answer they had to the equation went up in flames when Aleix Vidal picked up an injury a few months ago.