The special edition of the iPhone 7 and iPhone 7 Plus will come in 128-gigabyte and 256GB configurations, starting at $749 (£699).
While Apple has long participated in the (Red) program, this marks the first time the company has employed the color in its marquee phone.
In the final calendar quarter of 2016, it led Apple to record sales of 78.3 million total iPhones, accounting for roughly two-thirds of the company's revenue for the three months.
With the iPhone 7, customers were already able to choose from jet black, black, silver, gold and rose gold.
Apple said that all the money raised by (Red) goes directly to fund HIV and AIDS grant that provide testing, counseling, treatment and prevention programs.