The Standard & Poor’s 500 lost 2.63 points, or 0.1 percent, to 2,469.91 after nine of the 11 sectors that make up the index logged losses.
The Dow Jones industrial average fell 66.90 points, or 0.3 percent, to 21,513.17.
The Nasdaq composite rose 23.05 points, or 0.4 percent, to 6,410.81.
The central bank also announced plans to start gradually paring its bond holdings later this year, a move that could cause rates to rise.
The euro dipped to $1.1645 from $1.1677 late Friday, the dollar ticked up to 111.11 Japanese yen from 111.04 yen and the British pound rose to $1.3036 from $1.3007.