central bank raised interest rates for the second time in three months last week, but the "dot plot" that shows each member's expectations for where rates will be in coming years changed little from the last meeting.
Theresa May is going to start touring the UK in an attempt to bring the country together and create more support for Article 50," said Naeem Aslam, chief market analyst at Think Markets, in a note.
The Dow Jones industrial average fell 8.76 points, or 0.04 percent, to close at 20,905.86, with Home Depot leading decliners and Caterpillar the top advancer.
The S&P 500 dropped 4.78 points, or 0.2 percent, to end at 2,373.47, with financials leading seven sectors lower and materials outperforming.
The Nasdaq composite rose 0.53 points, or 0.01 percent, to close at 5,901.53.